ECMC2019
European Chemokine and Cell Migration Conference


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Day 1 (Wednesday, 26 June 2019)

18:00-18:15 Welcome
18:15-18:45 Discovering Salamanca/University of Salamanca
Plenary lecture
18:45-19:00 Chairman: Gerry Graham (UK)
19:00-20:00 Ronen Alon (Israel)
Chemokine and integrin signals for leukocyte extravasation: implications for immunity and vaccination
20:00-22:00 Welcome Reception

Day 2 Thursday, 27 June 2019

Session: Tissue homeostasis
09:00-09:15 Chairman: Bernhard Moser (UK)
09:15-09:45 Andrés Hidalgo (Spain)
Homeostatic control of neutrophil migration
09:45-10:15 Reinhold Förster (Germany)
Homing of activated, lymph-derived T cells requires mechanical arrest and integrin-supported chemokine guidance
Short Talks
10:15-10:30 Tanja Hartmann(Germany)
Absence of kindlin-3 in B cells abrogates integrin activation by chemokines and B-cell receptor stimulation and causes loss of marginal zone B cells
10:30-10:45 Julia Gutjahr (UK)
The interplay of chemokine receptors ACKR1 and CXCR4 on bone marrow erythroid cells
10:45-11:00 Ariadni Kouzeli (UK)
Synergistic interaction of CXCL14 with homeostatic and inflammatory chemokines
11:00-11:30 Coffee break
Session: Tissue disease
11:30-11:45 Chairman: Phil Murphy (USA)
11:45-12:15 Françoise Bachelerie (France)
Host/Human Papillomavirus interactions: CXCL12 signaling in the commensal to pathogenic transition
12:15-12:45 Raffaella Bonecchi (Italy)
ACKR2 a checkpoint for immune responses against metastasis
Short Talks
12:45-13:00 Marco E. Bianchi (Italy)
Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
13:00-13:15 Vincent Rondeau (France)
Maintenance and differentiation of adult skeletal mesenchymal stromal elements and hematopoietic multipotent progenitors require efficient CXCR4 desensitization
13:15-13:30 Industrial sponsor pitches session
13:30-15:30 LUNCH
15:30-17:00 POSTER SESSION & FLASH PRESENTATIONS
Session: Immune response
17:00-17:15 Chairman: Marcus Thelen (Switzerland)
17:15-17:45 Jens V Stein (Switzerland)
Chemokine-dependent and -independent migration modes during CD8+ T cell immune responses
17:45-18:15 Yolanda R. Carrasco (Spain)
Shaping cell dynamics to regulate B cell function: molecular mechanisms involved
Short Talks
18:15-18:30 Njabulo Ngwenyama (USA)
CXCR3 Regulates CD4+ T Cell Cardiotropism in Pressure Overload Induced Cardiac Dysfunction Through Mechanisms Involving ICAM-1-Mediated Adhesion
18:30-18:45 Annalisa Del Prete (Italy)
The atypical receptor CCRL2 is essential for lung cancer immune surveillance
18:45-19:00 Valeria Mollica-Poeta (Italy)
A conditional and reporter mouse as new tool to study the expression and the function of ACKR2 in homeostasis and tumors
19:00-19:15 Caroline Anderson (UK)
Duals roles for CCL17 and CCL22 in CCR4-driven Th2 recruitment and in ACKR1-mediated retention of recirculating T cells in the bone marrow
19:30-20:30 University of Salamanca TOUR

Day 3 Friday, 28 June 2019

Session: Cell migration and signaling
09:00-09:15 Chairman: Mariagrazzia Uguccioni (Switzerland)
09:15-09:45 Daniel F. Legler (Germany)
Function of the membrane microdomain protein flotillin 2 in dendritic cell migration
09:45- 10:15 Javier Redondo (Spain)
How chemokines influence on epigenetic changes and the nuclear dynamics of leukemic cells
Short Talks
10:15-10:30 Gianluca D’Agostino (Switzerland)
The role of β-arrestins in cytoskeleton remodeling, chemotaxis and CXCR4 expression in cells stimulated with the CXCL12/HMGB1 heterocomplex
10:30-10:45 Gertrud Hjorto (Denmark)
Free GAG binding CCL21-tail boosts chemokine signaling and chemotactic potency
10:45-11:00 Laura Medina-Ruiz (UK)
Generation of a reporter mouse strain for the inflammatory CC chemokine receptors Ccr1, Ccr2, Ccr3 and Ccr5
11:00-11:30 Coffee break
Session: Cell Migration: beyond the chemokines
11:30-11:45 Chairman: Ronen Alon (Israel)
11:45- 12:15 Susana Fagerholm (Finland)
Beta2-integrins in immune cells: New roles for old players
12:15- 12:45 Michael Sixt (Austria)
Combining local and global navigation during leukocyte trafficking
Short Talks
12:45-13:00 Joaquín Teixidó (Spain)
Role of the 1 integrin-binding partner ICAP-1 in immune cell adhesion and differentiation
13:00-13:15 Pablo Vargas (France)
The microenvironments’ complexity defines chemotaxis in leukocytes
13:15-13:30 Douglas P. Dyer (UK)
Proteoglycans as mediators of the immune system; Chemokines and glycosaminoglycans collaboratively regulate leukocyte recruitment
13:30-15:30 LUNCH
15:30-17:00 POSTER SESSION
Session: Cell Migration: Cancer
17:00-17:15 Chairman: Antal Rot (UK)
17:15- 17:45 Mirella Georgouli (UK)
Regional activation of Myosin II in cancer cells drives tumour progression via a secretory cross-Talk with the Immune microenvironment
17:45- 18:15 Lasse Jensen (Sweden)
Regional activation of Myosin II in cancer cells drives tumour progression via a secretory cross-Talk with the Immune microenvironment
Short Talks
18:15-18:30 Giovanni Bernardini (Italy)
CXCR3 controls anti-myeloma efficacy of NK cells adoptively transferred for immunotherapy
18:30-18:45 Paloma Sánchez-Mateos (Spain)
CCL20 Expression by Tumor-Associated Macrophages Predicts Progression of Human Primary Cutaneous Melanoma
Special Session: Line Time of chemokines & general discussion
19:00-20:00 Sergio Lira ( USA)

Day 4 Saturday, 29 June 2019

Session: Chemokine Antagonists: Drug Discovery
09:00-09:15 Chairman: Thomas J Schall (USA)
09:15-09:45 Martin Gustavsson (Denmark)
Molecular Insights into the Mechanism of Chemokine Receptor Ligand Binding and Activation
09:45-10:15 Olav Larsen (Denmark)
Selective use of the second extracellular loop and binding pocket of CCR1, -2 and -5 for chemokine responses
Short Talks
10:15-10:30 Christopher Lynch (UK)
A knottin scaffold directs CXC-chemokine binding specificity of tick evasins
10:30-10:45 Mieke Metzemaekers (Belgium)
Natural modification of the neutrophil chemoattractant CXCL5 alters CXCR1/2 usage and enhances its monocyte agonistic activity
10:45-11:15 Coffee break
Session: Chemokines and infection
11:15-11:30 Chairman: Antonio Alcamí (Spain)
11:30- 12:00 Heather Hickman (USA)
Visualizing Antiviral Effector Cell Biology in vivo
12:00- 12:30 Sergio M. Pontejo (USA)
Identification of anionic phospholipids as new ligands for human and viral chemokines
Short Talks
12:30-12:45 Santiago F. González (Switzerland)
Inflammatory dendritic cells recognise influenza virus in the trachea via the C-type lectin receptor SIGN-R1 and promote the recruitment of protective NK cells.
12:45-13:00 Bernard Lagane (France)
Selection of particular CCR5 or CXCR4 conformations as a mechanism of evolution of HIV-1 phenotypic properties
13:00-13:15 Bruno Hernáez(Spain)
Global transcriptomic analysis of the modulation of the immune response by the ectromelia virus TNF receptor: contribution of the TNF and chemokine binding domains
13:15-13:30 Laura Bricio Moreno(USA)
Astrocyte-derived CXCL1 drives neutrophil transmigration and blood-brain barrier permeability in HSV encephalitis
13:30-15:30 LUNCH
Special Session: Women in Science
15:30-16:30 Amanda E.I. Proudfoot (France)
Session: Biophysical Methods to study cell movement
16:30-16:45 Chairman: Maria García-Parajo (Spain)
16:45-17:15 Verena Ruprecht (Spain)
Mechanisms of amoeboid cell transformation and mechanosensitive actomyosin network contractility in confined environments
17:15-17:45 Gregory Giannone (France)
Deciphering the spatiotemporal and mechanical regulation of actin regulators at the nanoscale
Short Talks
17:45-18:00 Eva García-Cuesta (Spain)
New insights in WHIM receptor biology
18:15-18:15 Rob Leurs (The Netherlands)
Optical control of chemokine receptor function
18:15-18:30 Paula Antonello (Switzerland)
The role of ACKR3 in B cell lymphoma transmigration and correlation with IgM expression
21:00 Reception and Gala Dinner

Day 5 Sunday, 30 June 2019

Departure