ECMC2019
European Chemokine and Cell Migration Conference
Download final program
Day 1 (Wednesday, 26 June 2019)
| 18:00-18:15 | Welcome |
| 18:15-18:45 | Discovering Salamanca/University of Salamanca |
| Plenary lecture | |
| 18:45-19:00 | Chairman: Gerry Graham (UK) |
| 19:00-20:00 |
Ronen Alon (Israel) Chemokine and integrin signals for leukocyte extravasation: implications for immunity and vaccination |
| 20:00-22:00 | Welcome Reception |
Day 2 Thursday, 27 June 2019
| Session: Tissue homeostasis | |
| 09:00-09:15 | Chairman: Bernhard Moser (UK) |
| 09:15-09:45 |
Andrés Hidalgo (Spain) Homeostatic control of neutrophil migration |
| 09:45-10:15 |
Reinhold Förster (Germany) Homing of activated, lymph-derived T cells requires mechanical arrest and integrin-supported chemokine guidance |
| Short Talks | |
| 10:15-10:30 |
Tanja Hartmann(Germany) Absence of kindlin-3 in B cells abrogates integrin activation by chemokines and B-cell receptor stimulation and causes loss of marginal zone B cells |
| 10:30-10:45 |
Julia Gutjahr (UK) The interplay of chemokine receptors ACKR1 and CXCR4 on bone marrow erythroid cells |
| 10:45-11:00 |
Ariadni Kouzeli (UK) Synergistic interaction of CXCL14 with homeostatic and inflammatory chemokines |
| 11:00-11:30 | Coffee break |
| Session: Tissue disease | |
| 11:30-11:45 | Chairman: Phil Murphy (USA) |
| 11:45-12:15 |
Françoise Bachelerie (France) Host/Human Papillomavirus interactions: CXCL12 signaling in the commensal to pathogenic transition |
| 12:15-12:45 |
Raffaella Bonecchi (Italy) ACKR2 a checkpoint for immune responses against metastasis |
| Short Talks | |
| 12:45-13:00 |
Marco E. Bianchi (Italy) Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment |
| 13:00-13:15 |
Vincent Rondeau (France) Maintenance and differentiation of adult skeletal mesenchymal stromal elements and hematopoietic multipotent progenitors require efficient CXCR4 desensitization |
| 13:15-13:30 | Industrial sponsor pitches session |
| 13:30-15:30 | LUNCH |
| 15:30-17:00 | POSTER SESSION & FLASH PRESENTATIONS |
| Session: Immune response | |
| 17:00-17:15 | Chairman: Marcus Thelen (Switzerland) |
| 17:15-17:45 |
Jens V Stein (Switzerland) Chemokine-dependent and -independent migration modes during CD8+ T cell immune responses |
| 17:45-18:15 |
Yolanda R. Carrasco (Spain) Shaping cell dynamics to regulate B cell function: molecular mechanisms involved |
| Short Talks | |
| 18:15-18:30 |
Njabulo Ngwenyama (USA) CXCR3 Regulates CD4+ T Cell Cardiotropism in Pressure Overload Induced Cardiac Dysfunction Through Mechanisms Involving ICAM-1-Mediated Adhesion |
| 18:30-18:45 |
Annalisa Del Prete (Italy) The atypical receptor CCRL2 is essential for lung cancer immune surveillance |
| 18:45-19:00 |
Valeria Mollica-Poeta (Italy) A conditional and reporter mouse as new tool to study the expression and the function of ACKR2 in homeostasis and tumors |
| 19:00-19:15 |
Caroline Anderson (UK) Duals roles for CCL17 and CCL22 in CCR4-driven Th2 recruitment and in ACKR1-mediated retention of recirculating T cells in the bone marrow |
| 19:30-20:30 | University of Salamanca TOUR |
Day 3 Friday, 28 June 2019
| Session: Cell migration and signaling | |
| 09:00-09:15 | Chairman: Mariagrazzia Uguccioni (Switzerland) |
| 09:15-09:45 |
Daniel F. Legler (Germany) Function of the membrane microdomain protein flotillin 2 in dendritic cell migration |
| 09:45- 10:15 |
Javier Redondo (Spain) How chemokines influence on epigenetic changes and the nuclear dynamics of leukemic cells |
| Short Talks | |
| 10:15-10:30 |
Gianluca D’Agostino (Switzerland) The role of β-arrestins in cytoskeleton remodeling, chemotaxis and CXCR4 expression in cells stimulated with the CXCL12/HMGB1 heterocomplex |
| 10:30-10:45 |
Gertrud Hjorto (Denmark) Free GAG binding CCL21-tail boosts chemokine signaling and chemotactic potency |
| 10:45-11:00 |
Laura Medina-Ruiz (UK) Generation of a reporter mouse strain for the inflammatory CC chemokine receptors Ccr1, Ccr2, Ccr3 and Ccr5 |
| 11:00-11:30 | Coffee break |
| Session: Cell Migration: beyond the chemokines | |
| 11:30-11:45 | Chairman: Ronen Alon (Israel) |
| 11:45- 12:15 |
Susana Fagerholm (Finland) Beta2-integrins in immune cells: New roles for old players |
| 12:15- 12:45 |
Michael Sixt (Austria) Combining local and global navigation during leukocyte trafficking |
| Short Talks | |
| 12:45-13:00 |
Joaquín Teixidó (Spain) Role of the 1 integrin-binding partner ICAP-1 in immune cell adhesion and differentiation |
| 13:00-13:15 |
Pablo Vargas (France) The microenvironments’ complexity defines chemotaxis in leukocytes |
| 13:15-13:30 |
Douglas P. Dyer (UK) Proteoglycans as mediators of the immune system; Chemokines and glycosaminoglycans collaboratively regulate leukocyte recruitment |
| 13:30-15:30 | LUNCH |
| 15:30-17:00 | POSTER SESSION |
| Session: Cell Migration: Cancer | |
| 17:00-17:15 | Chairman: Antal Rot (UK) |
| 17:15- 17:45 |
Mirella Georgouli (UK) Regional activation of Myosin II in cancer cells drives tumour progression via a secretory cross-Talk with the Immune microenvironment |
| 17:45- 18:15 |
Lasse Jensen (Sweden) Regional activation of Myosin II in cancer cells drives tumour progression via a secretory cross-Talk with the Immune microenvironment |
| Short Talks | |
| 18:15-18:30 |
Giovanni Bernardini (Italy) CXCR3 controls anti-myeloma efficacy of NK cells adoptively transferred for immunotherapy |
| 18:30-18:45 |
Paloma Sánchez-Mateos (Spain) CCL20 Expression by Tumor-Associated Macrophages Predicts Progression of Human Primary Cutaneous Melanoma |
| Special Session: Line Time of chemokines & general discussion | |
| 19:00-20:00 | Sergio Lira ( USA) |
Day 4 Saturday, 29 June 2019
| Session: Chemokine Antagonists: Drug Discovery | |
| 09:00-09:15 | Chairman: Thomas J Schall (USA) |
| 09:15-09:45 |
Martin Gustavsson (Denmark) Molecular Insights into the Mechanism of Chemokine Receptor Ligand Binding and Activation |
| 09:45-10:15 |
Olav Larsen (Denmark) Selective use of the second extracellular loop and binding pocket of CCR1, -2 and -5 for chemokine responses |
| Short Talks | |
| 10:15-10:30 |
Christopher Lynch (UK) A knottin scaffold directs CXC-chemokine binding specificity of tick evasins |
| 10:30-10:45 |
Mieke Metzemaekers (Belgium) Natural modification of the neutrophil chemoattractant CXCL5 alters CXCR1/2 usage and enhances its monocyte agonistic activity |
| 10:45-11:15 | Coffee break |
| Session: Chemokines and infection | |
| 11:15-11:30 | Chairman: Antonio Alcamí (Spain) |
| 11:30- 12:00 |
Heather Hickman (USA) Visualizing Antiviral Effector Cell Biology in vivo |
| 12:00- 12:30 |
Sergio M. Pontejo (USA) Identification of anionic phospholipids as new ligands for human and viral chemokines |
| Short Talks | |
| 12:30-12:45 |
Santiago F. González (Switzerland) Inflammatory dendritic cells recognise influenza virus in the trachea via the C-type lectin receptor SIGN-R1 and promote the recruitment of protective NK cells. |
| 12:45-13:00 |
Bernard Lagane (France) Selection of particular CCR5 or CXCR4 conformations as a mechanism of evolution of HIV-1 phenotypic properties |
| 13:00-13:15 |
Bruno Hernáez(Spain) Global transcriptomic analysis of the modulation of the immune response by the ectromelia virus TNF receptor: contribution of the TNF and chemokine binding domains |
| 13:15-13:30 |
Laura Bricio Moreno(USA) Astrocyte-derived CXCL1 drives neutrophil transmigration and blood-brain barrier permeability in HSV encephalitis |
| 13:30-15:30 | LUNCH |
| Special Session: Women in Science | |
| 15:30-16:30 | Amanda E.I. Proudfoot (France) |
| Session: Biophysical Methods to study cell movement | |
| 16:30-16:45 | Chairman: Maria García-Parajo (Spain) |
| 16:45-17:15 |
Verena Ruprecht (Spain) Mechanisms of amoeboid cell transformation and mechanosensitive actomyosin network contractility in confined environments |
| 17:15-17:45 |
Gregory Giannone (France) Deciphering the spatiotemporal and mechanical regulation of actin regulators at the nanoscale |
| Short Talks | |
| 17:45-18:00 |
Eva García-Cuesta (Spain) New insights in WHIM receptor biology |
| 18:15-18:15 |
Rob Leurs (The Netherlands) Optical control of chemokine receptor function |
| 18:15-18:30 |
Paula Antonello (Switzerland) The role of ACKR3 in B cell lymphoma transmigration and correlation with IgM expression |
| 21:00 | Reception and Gala Dinner |
Day 5 Sunday, 30 June 2019
| Departure |